API |
IMPURITY |
CHEMICAL NAME |
STRUCTURE |
Atorvastatin |
EP Impurity B |
(3S,5R)-7-[3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt |  |
Atorvastatin |
EP Impurity D |
3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2-carboxylic acid phenylamide |  |
Atorvastatin |
Atorvastatin-2-hydroxy impurity |
(3R,5R)-7-(3-(2-hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid |  |
Atorvastatin |
Atorvastatin-4-hydroxy impurity |
(3R,5R)-7-(3-(4-hydroxyphenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoic acid |  |
Atorvastatin |
EP Impurity F |
(3R,5R)-7-{(3R,5R)-7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanamido}-3,5-dihydroxyheptanoic acid calcium salt |  |
Atorvastatin |
Ep Impurity G(Ats-3-O-methyl) |
(3R,5R)-7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-5-hydroxy-3-methoxyheptanoic acid calcium salt |  |
Atorvastatin |
Atorvastatin Acetonide impurity |
2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid |  |
Atorvastatin |
Atorvastatin Lactone impurity |
5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |  |
Atorvastatin |
ATS-L-1 impurity |
tert-butyl 2-((4R,6R)-6-(2-(3-(phenylcarbamoyl)-2-isopropyl-4,5-diphenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate |  |
Atorvastatin |
Methyl ester impurity |
(3R,5R)-methyl 7-(3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate |  |
Atorvastatin |
Atorvastatin Related Compound A |
Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl-4,5-diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt) |  |
Atorvastatin |
Atorvastatin Related Compound B |
(3S,5R isomer, or (3S,5R)-7-[3-(phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt) |  |
Atorvastatin |
Atorvastatin Related Compound C |
(Difluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-4,5-bis(4-fluorophenyl)-2-isopropyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt) |  |
Atorvastatin |
Atorvastatin Related Compound D |
(Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2-carboxylic acid phenylamide) |  |
Atorvastatin |
Atorvastatin Related Compound E |
(3S, 5S enantiomer of Atorvastatin Calcium) |  |
Atorvastatin Lactone (Impurity H) |
Atorvastatin Lactone (Impurity H) |
5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide |  |
Oxo Atorvastatin |
Oxo Atorvastatin |
7-[3-(Phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-heptanoic acid sodium salt |  |
ATORVASTATIN AMIDE |
ATORVASTATIN AMIDE |
(3R,5R)-7-[[(3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl] amino]-3,5-dihydroxy-heptanoic acid sodium salt |  |
ATORVASTATIN PYRROLIDONE LACTONE |
ATORVASTATIN PYRROLIDONE LACTONE |
5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3-isopropyl-2-oxo-N,4-diphenyl-2,3-dihydro-1H-pyrrole-3-carboxamide |  |
ATORVASTATIN AMIDE |
ATORVASTATIN AMIDE |
(3R,5R)-7-[[(3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl] amino]-3,5-dihydroxy-heptanoic acid sodium salt |  |
ATORVASTATIN AMIDE |
ATORVASTATIN AMIDE |
(3R,5R)-7-[[(3R,5R)-7-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3,5-dihydroxy-1-oxoheptyl] amino]-3,5-dihydroxy-heptanoic acid sodium salt |  |
ATORVASTATIN PYRROLIDONE LACTONE |
ATORVASTATIN PYRROLIDONE LACTONE |
5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3-isopropyl-2-oxo-N,4-diphenyl-2,3-dihydro-1H-pyrrole-3-carboxamide |  |
Atorvastatin Lactone (Impurity H) |
Atorvastatin Lactone (Impurity H) |
5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide |  |
ATORVASTATIN EPOXY PYRROLOOXAZIN 6-HYDROXY ANALOG |
ATORVASTATIN EPOXY PYRROLOOXAZIN 6-HYDROXY ANALOG. |
"4-{6-(4-Fluorophenyl)-7,8-epoxy-6-hydroxy-8a-isopropyl-7-phenyl-8-(phenylcarbamoyl)hexahydro-2H-pyrrolo[2,1-b][1,3]oxazin-2-yl}-3-hydroxybutanoic acid sodium salt. " |  |
ATORVASTATIN RELATED COMPOUND-E(ENANTIOMER) |
ATORVASTATIN RELATED COMPOUND-E(ENANTIOMER) |
(3S,5S)-7-[3-(Phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid. |  |