API
IMPURITY
CHEMICAL NAME
STRUCTURE
2
Ramipril

EP Impurity B

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-[(1-methylethoxy)carbonyl]-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (ramiprilisopropyl ester) Ramipril-EP-Impurity-B
Ramipril

EP Impurity C

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-3-cyclohexyl-1-(ethoxycarbonyl)-propyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (hexahydroramipril) Ramipril-EP-Impurity-C
Ramipril

EP Impurity D

ethyl (2S)-2-[(3S,5aS,8aS,9aS)-3-methyl-1,4-dioxodecahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl]-4-phenylbutanoate (ramipril diketopiperazine) Ramipril-EP-Impurity-D
Ramipril

EP Impurity G

methylbenzene Ramipril-EP-Impurity-G
Ramipril

EP Impurity E

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-carboxy-3phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid (ramipril diacid) Ramipril-EP-Impurity-E
Ramipril

Ramipril Impurity

Benzyl(cis,endo)-octahydrocyclopenta[b]pyrrole-2(S)-carboxylate hydrochloride Ramipril-Impurity
Ramipril

Ramipril Impurity

N-[1(S)-Carboethoxy-3-phenylpropyl]-(S)-alanine Ramipril-Impurity-N-[1(S)-Carboethoxy
RAMIPRIL IMPURITY-N

RAMIPRIL IMPURITY-N

(2R,3aR,6aR)-1-[(S)-2-[[(S)-1-(ethoxycarbonyl)-3phenylpropyl]amino]propanoyl]octahydrocyclopenta [b] pyrrole-2-carboxylic acid di cyclohexylamine salt. RAMIPRIL IMPURITY-N