API
IMPURITY
CHEMICAL NAME
STRUCTURE
2
Ritonavir

Ritonavir Impurity

gama-(S)-Amino alpha- (1S)-(thiazoly methyloxycarbonyl)-amino-(2-phenylethyl)- (S)-benzene butanol Ritonavir-Impurity
Ritonavir

EP Impurity A

N-[[(methyl[[2-(1-methylethyl)-4-thiazoyl]methyl]amino]carbonyl]-L-valine EP-Impurity-A-N-[[(methyl[[2-(1-methylethyl)
Ritonavir

EP Impurity T

(2S)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol-4-yl]mehtyl]carbamoyl]amino]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[[methyl[[2-(1-methylethyl)thiazol-4-yl]mehtyl]carbamoyl]amino]butanamide Ritonavir-EP-Impurity-T
N-DEACYLVALINE (Ritonavir Impurity B)

N-DEACYLVALINE (Ritonavir Impurity B)

"Thiazol-5-ylmethyl (2S ,3S ,5S )-5-[(S )-2-amino-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate " N-DEACYLVALINE
Ritonavir Impurity G

Ritonavir Impurity G

Thiazol-5-ylmethyl[(1s,2s,4s)-1-benzyl-4-[[(2s)-2-[[[2-(1-hydroperoxy-1-methyl)thiazol-4-yl]methyl]aminol]-3-methylbutanoyl]-amino]-2-hydroxy-5-phentyl]carbamate, Ritonavir Impurity G
(Ritonavir Impurity F) HYDANTOIN AMINO ALCOHOL IMPURITY

(Ritonavir Impurity F) HYDANTOIN AMINO ALCOHOL IMPURITY

Thiazol-5-ylmethyl (2S ,3S ,5S )-3-hydroxy-5-[(S )-4-isopropyl-2,5-dioxoimidazolidin-1-yl]- 1,6-diphenylhexan-2-ylcarbamate (Ritonavir Impurity F) HYDANTOIN AMINO ALCOHOL IMPURITY
Ritonavir Impurity E

Ritonavir Impurity E

thiazol-5-ylmethyl [(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-2-[[[[2-(1-hydroxy-1-methylethyl)thiazol-4-yl]methyl]methylcarbamoyl]amino]3methylbutanoyl]amino]-5phenylpentyl]carbamate Ritonavir Impurity E
Ritonavir Impurity N

Ritonavir Impurity N

"Thiazol-5-ylmethyl (2S ,4S ,5S )-4-hydroxy-5-[(S )-2-{3-[(2-isopropylthiazol-4-yl)methyl]-3-methylureido}-3-methylbutanamido]-1,6-diphenylhexan-2-ylcarbamate " Ritonavir Impurity N
RITONAVIR IMPURITY-L

RITONAVIR IMPURITY-L

(2S)-3-Methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amiS)-2-oxo-4-(phenylmethyl)-5-oxazolidinyl]methyl]-2-phenylethyl]-butanamide RITONAVIR IMPURITY
N-DEACYLVALINE (Ritonavir Impurity B)

N-DEACYLVALINE (Ritonavir Impurity B)

"Thiazol-5-ylmethyl (2S ,3S ,5S )-5-[(S )-2-amino-3-methylbutanamido]-3-hydroxy-1,6-diphenylhexan-2-ylcarbamate " rit1
HYDANTOIN AMINO ALCOHOL IMPURITY (Ritonavir Impurity F)

HYDANTOIN AMINO ALCOHOL IMPURITY (Ritonavir Impurity F)

"Thiazol-5-ylmethyl (2S ,3S ,5S )-3-hydroxy-5-[(S )-4-isopropyl-2,5-dioxoimidazolidin-1-yl]- 1,6-diphenylhexan-2-ylcarbamate " 18