API
IMPURITY
CHEMICAL NAME
STRUCTURE
2
Tadalafil

Tadalafil Impurity(Chloropretadalafil)

(IR,3R)-Methyl1,2,3,4-tetrahydro-2-chloroacetyl-(3,4-methylenedioxyphenyl)-9H-Pyrido[3,4-6]indole-3-carboxylate(Chloropretadalafil) Tadalafil-Impurity(Chloropretadalafil)
Tadalafil

TADALAFIL Impurity( cis-Tadalafil)

(6R-12aS)-2,3,6,7,12,12a-Hexahydro-2-mehtyl-6-(3,4-methylenedioxyphenyl)pyrazino[2,1:6]pyrido[3,4-6]indole-1,4-dione(cis-Tadalafil) TADALAFIL-Impurity(-cis-Tadalafil)
Tadalafil

Tadalafil impurity(ent-tadalafil)

(6S-12aS)-2,3,6,7,12,12a-Hexahydro-2-mehtyl-6-(3,4-methylenedioxyphenyl)pyrazilo[2,1:6]pyrido[3,4-6]indole-1,4-dione(ent-Tadalafil, L-Tadalafil; L-Tildenafil) Tadalafil-impurity(ent-tadalafil)
Tadalafil

Tadalafil Impurity(cis-ent-Tadalafil)

(6S-12aR) -2,3,6,7,12,12a-Hexahydro-2-mehtyl-6-(3,4-methylenedioxyphenyl)pyrazilo[2,1:6] pyrid0 [3,4-6] indole -1,4-dione(cis-ent-Tadalafil) Tadalafil-Impurity(cis-ent-Tadalafil)-(6S-12aR)
“Tadalafil impurity-(6S, 12aR)/6S,12aR Diastereomer/ Impurity C “

“Tadalafil impurity-(6S, 12aR)/6S,12aR Diastereomer/ Impurity C ”

(6S,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[ 1’ ,2’ :1,6]pyrido[3,4-b]indole-1,4-dione tadalif
” Tadalafil impurity-(6S, 12aS)/6S, 12aS Enantiomer/ Impurity B”

” Tadalafil impurity-(6S, 12aS)/6S, 12aS Enantiomer/ Impurity B”

(6S,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1¢,2¢:1,6]pyrido[3,4-b]indole-1,4-dione Tadalafil impurity-
Tadalafil impurity-(6S, 12aR)/6S,12aR Diastereomer/ Impurity C

Tadalafil impurity-(6S, 12aR)/6S,12aR Diastereomer/ Impurity C

(6S,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[ 1’ ,2’ :1,6]pyrido[3,4-b]indole-1,4-dione 222
Tadalafil impurity-(6R, 12aS)/6R, 12aS Diastereomer/Impurity A

Tadalafil impurity-(6R, 12aS)/6R, 12aS Diastereomer/Impurity A

(6R,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1’ ,2’ :1,6]pyrido[3,4-b]indole-1,4-dione vd
” Tadalafil impurity-(6S, 12aS)/6S, 12aS Enantiomer/ Impurity B”

” Tadalafil impurity-(6S, 12aS)/6S, 12aS Enantiomer/ Impurity B”

(6S,12aS)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1¢,2¢:1,6]pyrido[3,4-b]indole-1,4-dione 33