API
IMPURITY
CHEMICAL NAME
STRUCTURE
2
Brotizomibe

Brotizomibe Impurity B

N-(Pyrazine-2-ylcarbonyl)-L-Phenylalanine 26
Brotizomibe

Brotizomibe Impurity E

N-[(2S)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide 27
Brotizomibe

Brotizomibe Impurity A

N-[(2R)-1-{[(1R)-1-Hydroxy-3-methyl butyl]amino}-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide 25
Brotizomibe

Brotizomibe RR Isomer

[(1(R)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronicacid 29
Brotizomibe

Brotizomibe SRI Isomer

[(1S)-3-Methyl-1-({(2R)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl} amino)butyl]boronic acid 30